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NEURONTIN
(generic name: Gabapentin) |
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Reviews |
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Neurotin |
Addiction. 2005 Mar;100
Suppl 1:58-67.
A medication screening trial evaluation of reserpine,
gabapentin and lamotrigine pharmacotherapy of cocaine dependence.
Berger SP, Winhusen TM, Somoza EC, Harrer JM, Mezinskis
JP, Leiderman DB, Montgomery MA, Goldsmith RJ, Bloch DA, Singal BM, Elkashef
A.
Cincinnati VA/UC NIDA MDRU, VA Medical Center, Cincinnati, OH, USA.
ABSTRACT Aims To conduct a preliminary evaluation of the safety and efficacy
of reserpine, gabapentin or lamotrigine versus an unmatched placebo control
as a treatment for cocaine dependence. Design A 10-week out-patient study
using the Cocaine Rapid Efficacy and Safety Trial (CREST) study design.
Setting The study was conducted at the Cincinnati Medication Development
Research Unit (MDRU). Participants Participants met Diagnostic and Statistical
Manual version IV (DSM-IV) criteria for cocaine dependence. Sixty participants
were enrolled, with 50 participants completing the final study measures.
Intervention The targeted daily doses of medication were reserpine 0.5 mg,
gabapentin 1800 mg and lamotrigine 150 mg. All participants received 1 hour
of manualized individual cognitive behavioral therapy on a weekly basis.
Measurements Primary outcome measures of efficacy included urine benzoylecgonine
(BE) level, Cocaine Clinical Global Impression scale-observer and self-report
of cocaine use. Safety measures included adverse events, electrocardiograms
(ECGs), vital signs and laboratory tests. Findings Subjective measures of
cocaine dependence indicated significant improvement for all study groups.
Urine BE results indicated a significant improvement for the reserpine group
(P < 0.05) and non-significant changes for the other study groups. No
pattern of physical or laboratory abnormalities attributable to treatment
with any of the medications was identified. There were three serious adverse
events reported, none of which were related to study procedures. The medications
appeared to be tolerated well. Conclusions The present findings suggest
that reserpine may be worthy of further study as a cocaine dependence treatment. |
Int J Pharm. 2005
Mar 23;292(1-2):195-9. Epub 2005 Jan 20.
Microbiological
assay of ketoconazole in shampoo.
Staub I,
Schapoval EE, Bergold AM.
Programa de Pos-Graduacao em Ciencias
Farmaceuticas, UFRGS, Av. Ipiranga 2752 Porto Alegre CEP 90610-000, Brasil.
Ketoconazole, an anti-fungal agent, is often incorporated in several pharmaceutical
forms and in shampoo formulation it is known to be effective against fungal
infection on the scalp. This paper describes a method to quantify ketoconazole
in shampoo by comparing the cylinder plate assay and the HPLC method. The
test organism used for the agar diffusion assay was Candida albicans ATCC
10231. Three different concentrations of ketoconazole were used for the
diffusion assay. A mean zone diameter was obtained for each concentration.
A standard curve was obtained by plotting the three values derived from
the zone diameters. A prospective validation of the method showed that the
method was linear (r=0.9982), precise (R.S.D.=2.57%) and accurate. The results
obtained by the two methods were statistically evaluated by analysis of
variance (ANOVA) and the results obtained indicate that there is no significant
difference between these two methods. |
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Drug information |
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| GENERIC NAME: gabapentin
BRAND NAME: Neurontin
DRUG CLASS AND MECHANISM: Gabapentin is in the class
of drugs called anticonvulsants because they are used to treat seizures
(epilepsy) and herpes zoster (shingles). Gabapentin is related to the
brain chemical gamma aminobutyric acid (GABA) but exactly how it works
is unknown.
PREPARATIONS: Capsules are available in 100mg, 300mg,
400mg, and 800mg sizes by Park-Davis labs.
STORAGE: Store in a dry place at 15-30 degrees C (69-86
F)
PRESCRIBED FOR: Gabapentin is used for treating seizure
disorders and herpes zoster (shingles).
DOSING: Gabapentin can be taken with or without food
at doses specifically directed by your physician. Individual doses vary
greatly between individuals. Usually the drug is taken two to three times
daily. It is currently not approved under the age of 12 years old. If
discontinued, gabapentin should be gradually withdrawn (usually over one
week) as directed by the doctor.
DRUG INTERACTIONS: Gabapentin appears to be relatively
safe and has not been shown to interact with other drugs except for it's
potential of added sedation. Gabapentin should not be taken within 2 hours
of Maalox. Gabapentin may interfere with the reading of N- Multistix in
detecting urine protein.
SIDE EFFECTS: Neurontin has few side effects which include
sleepiness, dizziness, unsteady gait, fatigue and eye twitching.
Caution! Before starting to take this medicine,
it is vital that you should consult your doctor! Do not use it on your
own initiative, without medical advice.
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Order now ! |
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NEURONTIN
Substance: Gabapentin
Manufacturer: Pfizer
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Dosage |
Packing |
Price |
Pay now |
100 mg |
100 caps |
USD 67.00 |
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300 mg |
100 caps |
USD 149.00 |
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400 mg |
100 caps |
USD 158.00 |
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