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Ann Pharmacother. 2002 Sep;36(9):1443-52.
Herbs for benign prostatic hyperplasia.
Dvorkin L, Song KY.
Center for Integrative Therapies in Pharmaceutical Care, Massachusetts
College of Pharmacy and Health Sciences, Boston, MA 02115-5896, USA.
OBJECTIVE: To review and evaluate the literature relative to the use of
herbal therapies in the treatment of benign prostatic hyperplasia. DATA
SOURCES: Literature was identified by MEDLINE, Embase, International Pharmaceutical
Abstracts, and the International Bibliographic Information on Dietary
Supplements searches and through cross-referencing of selected articles.
STUDY SELECTION/DATA EXTRACTION: All articles identified from the data
sources were evaluated and all information deemed relevant was included
in this review. DATA SYNTHESIS: A large percentage of men >50 years
old begin to experience signs and symptoms of benign prostatic hyperplasia
(BPH). Herbs hold promise in the treatment of BPH. Serenoa repens, Pygeum
africanum, Urtica dioica radix, and Cucurbita peponis semen are some of
the botanical therapies used in the treatment of BPH. CONCLUSIONS: There
are many European studies examining efficacy, dose, and adverse effects
of these plants in the treatment of BPH. However, numerous questions remain.
These include issues concerning long-term beneficial and adverse effects
of herbal therapy, prevention of complications, standardization of extracts,
and concomitant use with "mainstream" medications. Based on
the information available today, these botanical therapies can be used
for treatment of a number of objective and subjective symptoms in patients
with BPH, stages I and II.
Int Urol Nephrol. 1991;23(1):51-5.
Experience with the Peponen capsule in the management of benign prostatic
hyperplasia.
Hamvas A, Corradi G, Hegedus M, Frang D.
Department of Urology, Semmelweis University Medical School, Budapest,
Hungary.
Sixty patients in Stages I and II of benign prostatic hyperplasia were
treated with Peponen capsule. Out of them 26 took the drug for 10 months,
22 for at least 7, and 12 for at least 4 months. The daily dosage was
3 x 2 capsules in the first month and 3 x 1 capsule for the rest of the
time. On the ground of urodynamic test results and changes in subjective
complaints, more than 80% of the patients experienced improvement. The
therapy intensified the uroflow, appeased dysuria, the difficult and painful
discharge, and reduced the frequency of nocturnal urination.
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